notch signaling

基本解释

This made a prediction that Notch signaling should be active in stem cells and mostly inactive during commitment.
这样就有一个预测是，Notch信号在干细胞中应该是有活性的，而在定向的过程中是几乎没有活性的。
Specifically we show that Notch signaling is highly active in hematopoietic stem cells (HSCs), and is critical for maintaining their undifferentiated state.
明确的讲我们展示了Notch信号在造血干细胞是高度有活性的，而且对于维持它们的分化状态是很关键的。
We set up in collaboration with him and this allowed us to show that Notch signaling was in fact highly enriched in stem cells, and was rapidly shut off as stem cells differentiated.
我们和他进行了合作，这就让我们表明了Notch信号事实上在干细胞中是很多见的，而一旦干细胞开始分化它就会中断了。