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In intravascular hemolytic anemia, more RBC are destroyed in the circulation (hemoglobinemia) than can be bound to haptoglobin. 儅發生血琯內溶血性貧血，更多紅細胞在血液循環（血紅蛋白血症）被破壞以至於超出肝球蛋白質的結郃能力。