irrevocable

1. ADJ If a decision, action, or change is irrevocable, it cannot be changed or reversed. 不可改变的[正式]

He said the decision was irrevocable. 他说过这项决定是不可改变的。

2. irrevocablyADV 不可改变地

My relationships with friends have been irrevocably altered by their reactions to my illness. 由于朋友们对我的病情所做出的反应，我和他们的关系已经彻底改变了。